Current Issue : January-March Volume : 2014 Issue Number : 1 Articles : 1 Articles
In market solid orals gain maximum popularity, because of many advantages over others. Orally disintegrating tablets (FDTs) are an emerging trend in novel drug delivery system (NDDS) and have received ever-increasing demand during the last few decades.FDTs disintegrates or dissolves rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, from which disintegrant is the key adjuvant. Diverse categories of superdisintegrants such as synthetic,semi-synthetic,natural and co-processed blends etc. The present review comprises the various kinds of superdisintegrants like natural and synthetic which are being used in the formulation to provide the safer, effective drug delivery with patient''s compliance and improve efficacy of dosage form. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Super-disintegrants are generally effective in a low concentration, and generally at higher concentrations they hinder disintegration. The present review describes super-disintegrants, their types, selection criteria and various methods of incorporating disintegrants and mechanism of tablet disintegration....
Loading....